Hücre Döngüsü Nedir?

The eukaryotic cell cycle consists of interphase and the mitotic phase. During interphase, the cell grows, performs metabolic functions, replicates its DNA, and prepares for division. The mitotic phase includes mitosis and cytokinesis, where the cell divides its nuclear and cytoplasmic materials to generate two identical daughter cells.

The cell cycle enables organisms to grow from a single zygote into multicellular individuals through controlled cell division. In adults, the cell cycle continues to replace damaged cells and regenerate aged tissues. Single-celled organisms use cell division for reproduction via binary fission, while multicellular organisms depend on it for development and homeostasis.

The G1 checkpoint evaluates whether a cell is ready to proceed to DNA replication. The cell assesses its size, energy levels, nutrient availability, DNA quality, and external factors. If conditions are inadequate, the cell does not advance to the S phase of interphase, preventing damaged or unprepared cells from replicating.

The G2 checkpoint ensures all DNA has been completely replicated and is undamaged before the cell enters mitosis. If unrepairable DNA damage is detected, the cell may undergo apoptosis, or programmed cell death, preventing the transmission of mutations to daughter cells.

Cancer cells bypass normal cell cycle checkpoints, allowing uncontrolled division and accumulation of mutations. Normal cells can divide only 40-60 times, but cancer cells express telomerase, an enzyme that repairs chromosome ends and enables unlimited division. This unchecked proliferation produces increasingly damaged daughter cells.

The M or spindle checkpoint verifies that all sister chromatids are correctly attached to spindle microtubules at the metaphase plate before anaphase begins. This checkpoint prevents cells with misaligned chromosomes from dividing, ensuring each daughter cell receives the correct genetic material.

Cancer results from gene mutations that cause loss of control over the normal cell cycle regulation. When cell cycle checkpoints are bypassed, cells divide uncontrollably, and each successive round of division produces more damaged daughter cells. This unchecked proliferation eventually leads to tumor formation and disease progression.