Fiber Scaffold Fabrication
Fiber Scaffold Fabrication - Related Videos
09:32
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
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Cited by 5 •
2015
Here, we present a protocol to fabricate electrospun nanofiber scaffolds with gradated organization of fibers and explore their applications in regulating cell morphology/orientation. Gradients with regard to physical and chemical properties of the nanofiber scaffolds offer a wide variety of applications in the biomedical field.
11:13
Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
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Cited by 3 •
2015
Scaffolds for tissue engineering need to recapitulate the complex biochemical and biophysical microenvironment of the cellular niche. Here, we show the use of interfacial polyelectrolyte complexation fibers as a platform to create composite, multi-component polymeric scaffolds with sustained biochemical release.
11:57
Fabricating Metamaterials Using the Fiber Drawing Method
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Cited by 23 •
2012
Metamaterials at terahertz frequencies offer unique opportunities, but are challenging to fabricate in bulk. We adapt the fabrication procedure for microstructured polymer optical fibers to inexpensively fabricate metamaterials potentially on an industrial scale. We produce polymethylmethacrylate fibers containing ~10 μm diameter indium wires separated by ~100 μm, which exhibit a terahertz plasmonic response.
12:21
Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
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Cited by 5 •
2017
This manuscript describes the procedure to fabricate and characterize Griffithsin-modified poly(lactic-co-glycolic acid) electrospun fibers that demonstrate potent adhesive and antiviral activity against human immunodeficiency virus type 1 infection in vitro. Methods used to synthesize, surface-modify, and characterize the resulting morphology, conjugation, and desorption of Griffithsin from surface-modified fibers are described.
09:56
Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
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Cited by 11 •
2015
Bioactive and mechanically reliable metal scaffolds have been fabricated through a method which consists of two processes, dynamic freeze casting for the fabrication of porous Ti, and coating and densification of the Ti scaffolds. The densification process is simple, effective and applicable to the fabrication of functionally graded scaffolds.
FAQs
Electrospinning uses an electric field to draw a polymer solution or melt into fine fibers. As the material is stretched and deposited, the resulting network can be adjusted through structural features such as fiber diameter, alignment, and porosity. These variables give researchers control over how closely the scaffold reproduces selected physical aspects of an extracellular matrix.
These features directly influence the scaffold’s biological and mechanical behavior. Fiber diameter and alignment affect how cells interact with and organize along the material, while porosity helps determine nutrient transport through the network. Together, they also influence mechanical properties, so changing the architecture can alter cell growth, tissue organization, and the scaffold’s functional performance.
A fibrous network provides structural cues that can guide cell attachment, growth, and organization. Its alignment may encourage cells to follow a particular orientation, while its porous structure affects access to nutrients. Because these physical conditions shape cell interactions, researchers can use architectural control to support tissue formation and regulate biological responses in engineered environments.
The process begins with a polymer prepared as either a solution or a melt. An electric field then draws this material into fine fibers, which are deposited to form a three-dimensional porous network. During fabrication, researchers focus on the resulting fiber diameter, alignment, and porosity because these characteristics determine how the scaffold may perform in later biological studies.
The central material is a polymer supplied as a solution or melt, and the essential processing condition is an applied electric field. The deposited fibers must form a porous three-dimensional network with suitable structural characteristics. Controlling diameter, alignment, and porosity is important because these properties connect fabrication conditions with nutrient transport, mechanical behavior, and cell interactions.
This approach is useful when researchers need a structured material to support or study biological organization. Applications described for fiber scaffolds include tissue engineering, regenerative medicine, drug delivery, and in vitro models. In these settings, the scaffolds can guide tissue formation, provide a matrix-like environment, and improve control over biological responses while allowing key structural features to be tuned.