Syringe Needle Model
Syringe Needle Model - Related Videos
05:49
Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
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Cited by 2 •
2021
Here we demonstrate a method to apply fluid shear stress to cancer cells in suspension to model the effects of hemodynamic stress on circulating tumor cells.
02:28
Extraction of Apoplastic Bacteria Using a Syringe-Based Pressure Method
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2025
Source: Rufián, J. S., et al, Single-Cell Analysis of the Expression of Pseudomonas syringae Genes within the Plant Tissue. J. Vis. Exp. (2022)This video demonstrates a syringe-based pressure method for extracting apoplastic bacteria, which proliferate and form microcolonies within the apoplast, the intercellular space between plant cells. The method yields debris-free bacterial samples suitable for downstream single-cell analysis.
09:51
Intraosseous Needle Placement
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2023
Source: Julianna Jung, MD, FACEP, Associate Professor of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA For unstable patients requiring urgent administration of medications, fluids, or blood products, establishing vascular access quickly is essential. However, there are many factors that can complicate placement of a peripheral intravenous cannula (PIV), and it is extremely common for PIV attempts to fail. PIV placement may be technically challenging in small...
10:06
Personalized Needles for Microinjections in the Rodent Brain
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Cited by 3 •
2018
We describe here a protocol for microinjection in the rodent brain that uses quartz needles. These needles do not produce detectable tissue damage and ensure reliable delivery even in deep regions. Moreover, they can be adapted to research needs by personalized designs and can be re-used.
08:25
Needle Thoracostomy
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2015
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA A tension pneumothorax is a life-threatening situation in which excess air is introduced into the pleural space surrounding the lung, either through trauma to the chest cavity or as a spontaneous leak of air from the lung itself. Air trapped within the pleural space causes separation of the lung from the chest wall, disrupting normal breathing mechanisms. Pneumothorax may be small without...
FAQs
Needle geometry is a controllable variable that can change how the needle enters a target and how fluid moves during delivery or aspiration. Researchers can compare designs under the same plunger-driven pressure, fluid, and target material conditions. This helps separate effects caused by the needle itself from effects caused by the surrounding experimental setup.
Plunger-driven pressure provides the force that moves fluid through the needle, making delivery conditions controllable and comparable. Changes in pressure can be examined alongside fluid flow and needle geometry to evaluate how the system behaves under defined conditions. Controlling this factor is important when comparing delivery performance or interpreting differences in experimental outcomes.
Target-material resistance determines how much mechanical force the needle encounters during penetration. In a syringe needle model, researchers can examine this resistance together with needle geometry and fluid-delivery conditions rather than treating insertion as an isolated event. The resulting measurements or comparisons can clarify how a needle behaves when entering tissue or tumor-mimicking materials.
A useful experimental comparison keeps needle geometry, plunger-driven pressure, fluid flow, and target-material resistance defined and consistent. Researchers can then change one selected condition while observing delivery or insertion behavior. This standardization reduces ambiguity in the results and supports systematic comparisons among needle designs, delivery conditions, and procedural outcomes.
The model can reproduce selected mechanical and fluid-delivery conditions relevant to penetrating tissue or tumor-mimicking materials. For tumor biopsy studies, it can help examine insertion forces and procedural behavior. For localized drug delivery, it can support comparisons of delivery conditions and needle designs before investigators consider translation to biological systems or clinical applications.
Experiments can reveal how defined needle designs, pressure conditions, fluid flow, and target resistance influence injection or aspiration behavior. These comparisons provide a controlled basis for evaluating procedural outcomes without immediately relying on biological systems. In cancer research, the findings can help inform later investigations of biopsy or localized delivery and support more deliberate clinical translation.