Cyclohexane Solvent
Cyclohexane Solvent - Related Videos
02:11
Conformations of Cyclohexane
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2023
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations. The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal tetrahedral value,...
02:02
Chair Conformation of Cyclohexane
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2023
The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds. The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this staggered...
04:54
Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
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Cited by 34 •
2017
Solvent bonding is a simple and versatile method for fabricating thermoplastic microfluidic devices with high quality bonds. We describe a protocol to achieve strong, optically clear bonds in PMMA and COP microfluidic devices that preserve microfeature details, by a judicious combination of pressure, temperature, an appropriate solvent, and device geometry.
06:43
Rotary Evaporation to Remove Solvent
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2023
Source: Dr. Melanie Pribisko Yen and Grace Tang — California Institute of Technology Rotary evaporation is a technique most commonly used in organic chemistry to remove a solvent from a higher-boiling point compound of interest. The rotary evaporator, or "rotovap", was invented in 1950 by the chemist Lyman C. Craig. The primary use of a rotovap is to dry and purify samples for downstream applications. Its speed and ability to handle large volumes of solvent make rotary evaporation a preferred...
09:41
Schlenk Lines Transfer of Solvents
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2023
Source: Hsin-Chun Chiu and Tyler J. Morin, laboratory of Dr. Ian Tonks—University of Minnesota Twin Cities Schlenk lines and high vacuum lines are both used to exclude moisture and oxygen from reactions by running reactions under a slight overpressure of inert gas (usually N2 or Ar) or under vacuum. Vacuum transfer has been developed as a method separate solvents (other volatile reagents) from drying agents (or other nonvolatile agents) and dispense them to reaction or storage vessels while...
FAQs
Its low polarity favors interactions with molecules that also lack strong polarity, allowing hydrophobic substances to enter and remain in the liquid phase. This behavior reflects the general principle that substances with similar polarity tend to dissolve one another. In practice, the solvent is therefore most suitable when the target material does not depend on strong ionic or hydrogen-bonding interactions for solubility.
Limited hydrogen-bonding ability reduces cyclohexane’s tendency to strongly interact with substances that rely on hydrogen bonding for dissolution. Instead, it preferentially supports interactions with relatively nonpolar materials. This distinction helps chemists decide whether cyclohexane is appropriate for a procedure, particularly when a compound’s polarity and hydrogen-bonding behavior determine whether it will dissolve in the selected solvent.
Cyclohexane is favored when a procedure requires a low-polarity medium, while a more polar solvent may be preferable for substances that need stronger polar interactions. The relevant comparison concerns how well each liquid matches the polarity of the material being handled. This choice influences whether compounds dissolve appropriately during extraction, chromatography, recrystallization, or reaction work.
In liquid-liquid extraction, cyclohexane can provide an organic phase for substances that preferentially dissolve in a nonpolar environment. Its usefulness depends on the target material’s polarity and compatibility with the solvent. Selecting it for this role can help separate hydrophobic substances from materials associated with another liquid phase, provided the overall solvent system is chosen to support the intended separation.
Cyclohexane serves as a low-polarity solvent in chromatographic procedures when the compounds being handled are compatible with a nonpolar medium. Its limited hydrogen-bonding capacity helps maintain the interaction pattern expected for hydrophobic substances. The solvent is selected as part of the chromatographic system, where matching solvent polarity to the compounds is important for obtaining useful movement and separation behavior.
Cyclohexane may be selected for recrystallization when the substances involved show suitable solubility behavior in this nonpolar solvent. Its value comes from providing a medium whose polarity matches hydrophobic materials, rather than from strong polar or hydrogen-bonding interactions. The choice must therefore be based on the specific compounds and the solubility pattern required for the recrystallization procedure.
Cyclohexane’s volatility and flammability require controlled handling, appropriate ventilation, and careful solvent selection. Laboratory procedures should account for these properties when establishing work conditions and choosing an organic medium for extraction, chromatography, recrystallization, or reactions. These precautions are part of method design because the solvent’s practical safety characteristics matter alongside its chemical suitability.