Maternal Edema

Maternal edema is the accumulation of excess fluid in the tissues during pregnancy, most often appearing as swelling in the feet, ankles, legs, or hands. As the uterus enlarges, it can compress pelvic veins and slow venous return, while pregnancy-related increases in blood volume and changes in vascular permeability promote movement of fluid into surrounding tissues. Mild, gradual swelling is common and can improve with rest, leg elevation, and avoiding prolonged standing, but sudden or severe edema, especially in the face or hands, may signal preeclampsia or another complication. Recognizing its pattern supports prenatal assessment, timely diagnosis, and appropriate maternal and fetal care.

Maternal Edema - Related Videos

Research

JoVE Journal - Developmental Biology

Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish

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2025

Here, we describe a protocol for generating maternal mutant that couples a stable zpc:cas9 knock-in line with Tol2-mediated delivery of sgRNA expression cassettes.

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Cited by 44 •

2015

Described herein is a protocol to isolate and analyze the infiltrating leukocytes of tissues at the maternal-fetal interface (uterus, decidua, and placenta) of mice. This protocol maintains the integrity of most cell surface markers and yields enough viable cells for downstream applications including flow cytometry analysis.

Research

JoVE Journal - Developmental Biology
Free Sample

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

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Cited by 27 •

2015

This protocol describes a technique to assess changes in the maternal vasculature during pregnancy in mice. Using stereological methods, remodeling of the decidual spiral arteries is assessed quantitatively and the results confirmed qualitatively using immunohistochemistry.

Education

JoVE Core - Pathophysiology

Pulmonary Edema II: Pathophysiology

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2026

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...

Cerebral Edema ll: Pathophysiology

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2026

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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