Schlemm's Canal
Schlemm's Canal - Related Videos
06:26
Capturing Flow-weighted Water and Suspended Particulates from Agricultural Canals During Drainage Events
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Cited by 2 •
2017
Nutrients present in particulate form can contribute significantly to the overall loads in agricultural drainage waters. This study describes a novel method to capture flow-weighted water and suspended particulates from farm canal drainage over the entire duration of the drainage event.
08:38
Testing of all Six Semicircular Canals with Video Head Impulse Test Systems
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Cited by 26 •
2019
This protocol describes how to correctly perform the video head impulse test with two separate test systems commonly used worldwide. Both the 2D and 3D video head impulse test methods are described.
10:30
The C. elegans Excretory Canal as a Model for Intracellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis in a Single Cell: labeling by GFP-fusions, RNAi Interaction Screen and Imaging
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Cited by 6 •
2017
The C. elegans excretory canal is a unique single-cell model for the visual in vivo analysis of de novo polarized membrane biogenesis. This protocol describes a combination of standard genetic/RNAi and imaging approaches, adaptable for the identification and characterization of molecules directing unicellular tubulogenesis, and apical membrane and lumen biogenesis.
09:03
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Cited by 7 •
2015
Trabecular meshwork (TM) migration into Schlemm’s canal space can be induced by acute pressure elevation by ophthalmodynamometer, and observed by spectral domain optical coherence tomography. The goal of this method is to quantify the morphometric response of the living outflow tract to acute pressure elevation in living tissues in situ.
03:52
Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
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Cited by 37 •
2018
In this study, we describe the posterior semicircular canal approach as a reliable method for inner ear gene delivery in neonatal mice. We show that gene delivery through the posterior semicircular canal is able to perfuse the entire inner ear.
FAQs
Resistance within the conventional outflow pathway slows the movement of aqueous humor away from the anterior chamber. When drainage cannot keep pace with fluid movement, aqueous humor accumulates and intraocular pressure rises. Persistently elevated pressure can increase the risk of optic nerve damage, which explains why outflow resistance is clinically important in glaucoma assessment.
After passing through the trabecular meshwork, aqueous humor enters Schlemm's canal and continues through collector channels before reaching the episcleral venous circulation. This sequence shows that effective drainage depends on several connected structures rather than on the canal alone. Resistance at any point in this route can impair conventional outflow and affect pressure regulation.
Collector channels provide the downstream connection between Schlemm's canal and the episcleral venous circulation. They therefore help complete the route by which aqueous humor leaves the eye. Even when fluid reaches Schlemm's canal, impaired passage through these channels could limit overall drainage, contributing to the resistance that influences intraocular pressure.
Evaluation of Schlemm's canal helps clinicians interpret how aqueous humor moves through the eye's conventional drainage pathway. Attention to the canal, trabecular meshwork, collector channels, and episcleral venous connection can help relate impaired outflow to elevated intraocular pressure. This information supports assessment of mechanisms relevant to glaucoma and potential outflow-directed treatment.
Treatments directed at conventional outflow seek to improve the movement of aqueous humor through the drainage pathway. The overview identifies medications and minimally invasive glaucoma procedures as approaches designed to enhance this route. Their relevance lies in reducing impaired drainage, which may help address the fluid accumulation and elevated intraocular pressure associated with outflow resistance.
Schlemm's canal links the study of aqueous humor dynamics with a major clinical concern: pressure-related optic nerve damage. Research on this pathway can clarify how drainage resistance contributes to elevated intraocular pressure and can inform treatments intended to improve conventional outflow. In medicine, that connection supports both clinical evaluation and procedure development for glaucoma.