In Vivo Muscle Manipulation
In Vivo Muscle Manipulation - Related Videos
14:02
Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
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Cited by 53 •
2012
We describe a method to directly measure muscle force, muscle power, contractile kinetics and fatigability of isolated skeletal muscles in an in vitro system using field stimulation. Valuable information on Ca2+ handling properties and contractile machinery of the muscle can be obtained using different stimulating protocols.
14:36
Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice
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Cited by 75 •
2013
Changes in limb muscle contractile and passive mechanical properties are important biomarkers for muscle diseases. This manuscript describes physiological assays to measure these properties in the murine extensor digitorum longus and tibialis anterior muscles.
09:34
In Vivo Canine Muscle Function Assay
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Cited by 19 •
2011
We describe a minimally-invasive and painless method to measure canine hindlimb muscle strength and muscle response to repeated eccentric contractions.
13:27
Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
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Cited by 50 •
2014
Pneumonia is one of the top ten leading causes of death in the U.S. Osteopathic manipulative techniques (OMT) may be utilized as an adjunctive therapy in the treatment of pneumonia to enhance biomechanical and immune function; and ultimately, to reduce hospital stay, duration of antibiotics, incidence of respiratory failure, and mortality. In this video-article, we will review randomized controlled studies on the use of OMT in pneumonia patients, as well as demonstrate specific hands-on...
08:33
In Vivo Imaging of Muscle-tendon Morphogenesis in Drosophila Pupae
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Cited by 17 •
2018
Here, we present an easy-to-use and versatile method to perform live imaging of developmental processes in general and muscle-tendon morphogenesis in particular in living Drosophila pupae.
FAQs
The key experimental advantage is that muscle responses can be interpreted together with sensory feedback. A change in contraction, force, length, or load may influence proprioceptive signals, which can then be related to motor-neuron activity, reflexes, and behavior. Preserving these links helps distinguish local muscle effects from changes emerging across the neuromuscular system.
These interventions alter different features of neuromuscular function within a living organism. Controlled stimulation changes muscle activation, while movement and loading modify mechanical conditions affecting muscles and sensory receptors. Surgical intervention provides another way to alter or examine function. Comparing the resulting contractions, sensory feedback, and neural responses helps investigators connect mechanical events with physiological control.
Maintaining these interactions allows researchers to study movement as a coordinated system rather than as an isolated muscle response. Brain and spinal mechanisms can be related to motor-neuron activity, peripheral nerves can be considered alongside muscle behavior, and proprioceptive receptors can be linked to reflexes and actions. This systems-level context is especially valuable for understanding motor control.
Investigators select a controlled way to change or assess muscle activity, force, length, or mechanical load, then examine the resulting neuromuscular responses. Measurements or observations can be related to contractions, sensory feedback, motor-neuron activity, reflexes, and behavior. The resulting relationships help connect a physical muscle perturbation with neural control and whole-organism function.
The experiments can reveal how changes in muscle mechanics correspond to neural activity, reflex responses, sensory feedback, and behavior. They may also show how muscles and joints participate in coordinated movement rather than acting independently. Because the observations occur in physiological context, researchers can relate cellular or neural mechanisms to functional outcomes across the organism.
This approach supports investigations of motor control, neural plasticity, injury, and disease by linking neuromuscular mechanisms with function. It also helps evaluate therapies and neural interfaces, since researchers can examine how interventions affect muscle behavior, sensory pathways, neural activity, and movement-related outcomes. Its value lies in testing these relationships while interactions among muscles, joints, and nervous-system pathways remain present.