Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

J. Andrew Taylor; Can Ozan Tan; J. W. Hamner

doi:10.3791/51082

Dergi

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Biyoloji

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Salınım Alt Vücut Negatif Basınç ve Projeksiyon Takip regresyon yoluyla Serebral otoregülasyonda Değerlendirilmesi

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

JoVE Journal
Biyoloji

This content is Free Access.

JoVE Journal Biyoloji

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Salınım Alt Vücut Negatif Basınç ve Projeksiyon Takip regresyon yoluyla Serebral otoregülasyonda Değerlendirilmesi

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12,325 Views

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11:26 min

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December 10, 2014

DOI:

10.3791/51082-v

DOI:

10.3791/51082-v

•

11:26 min

December 10, 2014

•

12320 Views

J. Andrew Taylor^1,2, Can Ozan Tan^1,2, J. W. Hamner²

¹Department of Physical Medicine and Rehabilitation,Harvard Tıp Fakültesi ²Cardiovascular Research Laboratory,Spaulding Hospital Cambridge

Özet

Cerebral perfusion is maintained across a range of pressures via cerebral autoregulation. However, characterizing autoregulation requires prominent pressure fluctuations at regulated frequencies. The described protocol will show how oscillatory lower body negative pressure can generate pressure fluctuations to provide data for projection pursuit regression for quantification of the autoregulatory curve.