Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Wei-Ting Chang; Sudeshna Fisch; Michael Chen; Yiling Qiu; Susan Cheng; Ronglih Liao

doi:10.3791/52598

Dergi

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Tıp

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Farelerde Basınç Aşırı Modeli Koroner Arter Akış ve Koroner Akım Rezervi Ultrason Dayalı Değerlendirme

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

JoVE Journal
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JoVE Journal Tıp

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Farelerde Basınç Aşırı Modeli Koroner Arter Akış ve Koroner Akım Rezervi Ultrason Dayalı Değerlendirme

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14,838 Views

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06:39 min

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April 13, 2015

DOI:

10.3791/52598-v

DOI:

10.3791/52598-v

•

06:39 min

April 13, 2015

•

7 Views

Wei-Ting Chang*^1,2, Sudeshna Fisch*¹, Michael Chen¹, Yiling Qiu¹, Susan Cheng¹, Ronglih Liao¹

¹Cardiac Muscle Research Laboratory, Cardiovascular Division,Brigham and Women’s Hospital, Harvard Medical School, ²Division of Cardiovascular Medicine,Chi-Mei Medical Center, Tainan

Özet

Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.