Karaciğer için Kapalı ckiabl Metastazına bir tedavi olarak Melfalan ile Perkütan karaciğer perfüzyon (PHP)

Overview

This manuscript describes percutaneous isolated hepatic perfusion with simultaneous chemofiltration as a treatment for unresectable liver metastases. The procedure is minimally invasive and performed under general anesthesia by a skilled team.

Key Study Components

Area of Science

• Interventional Radiology
• Oncology
• Minimally Invasive Surgery

Background

• Unresectable liver metastases pose significant treatment challenges.
• High-dose chemotherapy can be delivered directly to the liver.
• Minimally invasive techniques reduce recovery time.
• Simultaneous chemofiltration minimizes systemic exposure to chemotherapy.

Purpose of Study

• To evaluate the efficacy of percutaneous hepatic perfusion.
• To assess the safety and repeatability of the procedure.
• To demonstrate the procedure's advantages over traditional methods.

Methods Used

• Pre-procedural angiography performed days prior to the PHP.
• General anesthesia administered by an anesthesiologist.
• Collaboration between interventional radiologist and clinical perfusionist.
• Use of chemofiltration during the perfusion process.

Main Results

• High doses of chemotherapy delivered effectively to the liver.
• Low morbidity and mortality rates associated with the procedure.
• Procedure can be repeated for ongoing treatment.
• Demonstrated successful outcomes in patient cases.

Conclusions

• Percutaneous hepatic perfusion is a viable treatment for liver metastases.
• Minimally invasive nature enhances patient recovery.
• Further studies may expand its application in oncology.

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