A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Jiayin Yang; Lai-Yung Wong; Xiao-Yu Tian; Rui Wei; Wing-Hon Lai; Ka-Wing Au; Zhiwei Luo; Carl Ward; Wai-In Ho; David P. Iba&#241;ez; Hao Liu; Xichen Bao; Baoming Qin; Yu Huang; Miguel A. Esteban; Hung-Fat Tse

doi:10.3791/57556

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İndüklenmiş Pluripotent kök hücre kaynaklı tetkikine kullanarak ailesel hiperkolesterolemi insan karaciğer Chimeric fare modeli

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

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JoVE Journal Gelişim Biyolojisi

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

İndüklenmiş Pluripotent kök hücre kaynaklı tetkikine kullanarak ailesel hiperkolesterolemi insan karaciğer Chimeric fare modeli

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8,151 Views

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10:56 min

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September 15, 2018

DOI:

10.3791/57556-v

DOI:

10.3791/57556-v

•

10:56 min

September 15, 2018

•

8117 Views

Jiayin Yang*^1,2,6, Lai-Yung Wong*², Xiao-Yu Tian*³, Rui Wei^1,2, Wing-Hon Lai², Ka-Wing Au², Zhiwei Luo^4,5, Carl Ward^4,5, Wai-In Ho², David P. Ibañez^4,5, Hao Liu^4,5, Xichen Bao^4,5, Baoming Qin^4,5, Yu Huang³, Miguel A. Esteban^4,5,7, Hung-Fat Tse^1,2,6,7

¹Tıp Fakültesi,University of Hong Kong-Shenzhen Hospital ²The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine,University of Hong Kong ³School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences,Chinese University of Hong Kong ⁴Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University ⁵Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences ⁶Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine,University of Hong Kong ⁷Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre,University of Hong Kong and Guangzhou Institutes of Biomedicine and Health

Özet

Burada, ailesel hiperkolesterolemi insan indüklenmiş pluripotent kök hücre kaynaklı tetkikine kullanarak bir insan karaciğer chimeric fare modeli oluşturmak için bir protokol mevcut. Bu yeni tedaviler hiperkolesterolemi için test etmek için değerli bir modeldir.