Name: Sağlıklı ve İskemik Ex Vivo Sıçan Kalplerinde Çift Yönlü Elektrik ve Optoelektronik Arayüzler (Video) | JoVE Journal
Uploaded: 2025-07-18T13:20:00.000+00:00
Duration: 8 min 33 s
Description: Keşfedin çift yönlü elektrik ve optoelektronik arayüzlerle sağlıklı ve iskemik ex vivo sıçan kalplerinde biyoelektronik malzeme testleri. Bu yöntem kalp stimülasyonu, kayıt ve miyokard infarktüsü modellemesi için kullanılır.

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<table><tbody><tr><td>16 Kanal Sahne Alanı</td><td>İntan Teknolojileri</td><td>C3334 (İngilizce)</td><td></td></tr><tr><td>2,3,5-Trifeniltetrazolyum klorür</td><td>Sigma Aldrich</td><td>T8877-5G</td><td>Trifeniltetrazolyum klorür </td></tr><tr><td>2-Propanol (IPA) </td><td>Fischer Bilimsel</td><td>A451-4 Serisi</td><td></td></tr><tr><td>635 nm Lazer, 500 mW</td><td>Lazer parıltısı</td><td>NA</td><td></td></tr><tr><td>Aseton</td><td>Fischer Bilimsel</td><td>A18-4 Fırlatma Makinası</td><td></td></tr><tr><td>Angstrom Evovac e-ışın evaporatörü</td><td>Angstrom</td><td>NA</td><td></td></tr><tr><td>AZ 300MIF Geliştirici</td><td>Mikrokimyasallar</td><td>18441123163</td><td>Geliştirici</td></tr><tr><td>AZ nlof 2020 </td><td>Mikrokimyasallar</td><td>1A002020</td><td></td></tr><tr><td>AZ NMP </td><td>Mikrokimyasallar</td><td>NA</td><td>Fotorezist sökücü</td></tr><tr><td>AZ40XT-11D </td><td>Mikrokimyasallar</td><td>1000300</td><td>Fotorezist</td></tr><tr><td>Arabelleğe alınmış HF</td><td>Termo Bilimsel</td><td>AA44627K2</td><td></td></tr><tr><td>CaCl2.2H2O</td><td>Sigma Aldrich</td><td>(C3881)</td><td></td></tr><tr><td>CO2 lazer </td><td>Üniversal Lazer Sistemleri</td><td>VLS 4.60</td><td></td></tr><tr><td>İletken gümüş boya</td><td>PELCO</td><td>16062</td><td>Elektrot ve bağlantı Cu teli arasında iletken yapışma</td></tr><tr><td>0,1 mm kapsüllü bakır tel</td><td>Amazon</td><td>https://www.amazon.com/Enameled-Temperature-Resistance-Transformers-Inductors/dp/ B09TNM51S5/ref=asc_df_B09 TNM51S5?mcid=155de761ea4 c389ea86d45ba61a83e8d& etiket =hyprod-20& linkCode=df0& hvadid =693675076770& hvpos=& hvnetw =g& hvrand=664358781094905 4431& hvpone=& hvptwo=& hvqmt =& hvdev=c& hvdvcmdl=& hvlocint =& hvlocphy=9021716& hvtargid= pla-1878323158943& psc=1</td><td></td></tr><tr><td>Digidata 1550 sayısallaştırıcı</td><td>Moleküler Cihazlar</td><td>NA</td><td></td></tr><tr><td>Glikoz</td><td>Sigma Aldrich</td><td>G7021 Serisi</td><td></td></tr><tr><td>HBSS, kalsiyum yok, magnezyum yok, fenol kırmızısı yok</td><td>Termo Bilimsel</td><td>14175095</td><td></td></tr><tr><td>Heidelberg MLA150 doğrudan yazar</td><td>Heidelberg</td><td>NA</td><td></td></tr><tr><td>heparin (1000 IU/kg)</td><td>Sagent İlaç</td><td>1009655</td><td></td></tr><tr><td>HEPES</td><td>Sigma Aldrich</td><td>(H4034)</td><td></td></tr><tr><td>Hekzan </td><td>Sigma Aldrich</td><td>52750-10ML</td><td>Çözücü</td></tr><tr><td>HF</td><td>Fisher Bilimsel</td><td>A513-500 Cep Telefonu</td><td>İz metal kalitesi</td></tr><tr><td>HMDS Buharlı Prime Fırın</td><td>Verim Mühendisliği Sistemleri</td><td>NA</td><td></td></tr><tr><td>HNO3</td><td>Fisher Bilimsel</td><td>A509P500</td><td>İz metal kalitesi</td></tr><tr><td>Sıcak laminasyon makinesi</td><td>Ofis Deposu</td><td>L410-A</td><td>Çok katmanlı kapsülleme </td></tr><tr><td>Intan RHD sistemleri</td><td>İntan Teknolojileri</td><td>C3100 Serisi</td><td></td></tr><tr><td>iWorx EKG</td><td>iWorx</td><td> IA-400D</td><td></td></tr><tr><td>iWorx LVD sondası</td><td>iWorx</td><td>BP-100 Serisi</td><td></td></tr><tr><td>iWorx ön yükseltici</td><td>iWorx</td><td>C-ISO-256</td><td></td></tr><tr><td>Kartal</td><td>Sigma Aldrich</td><td>(P4504)</td><td></td></tr><tr><td>Lateks Balon (4 numara)</td><td>Radnoti Belediyesi</td><td>170404</td><td></td></tr><tr><td>MgCl2.7H2O</td><td>Sigma Aldrich</td><td>(M9272)</td><td></td></tr><tr><td>NaCl</td><td>Sigma Aldrich</td><td>(S9625)</td><td></td></tr><tr><td>Nafion 117 içeren çözelti</td><td>Sigma Aldrich</td><td>31175-20-9</td><td>Nano gözenekli karbon modeli için sabitleme reaktifi</td></tr><tr><td>NaH2PO4</td><td>Sigma Aldrich</td><td>(S0751)</td><td></td></tr><tr><td>NaOH</td><td>Sigma Aldrich</td><td>221465</td><td></td></tr><tr><td>PDMS</td><td>Fisher Bilimsel</td><td>NC9285739</td><td></td></tr><tr><td>Plasma-Therm endüktif olarak eşleşmiş plazma florür aşındırıcı</td><td>Plazma-Termal</td><td>NA</td><td></td></tr><tr><td>PMMA (495 A6) </td><td>Mikrokimyasallar</td><td>M130006 </td><td></td></tr><tr><td>Poli (piromelitik dianhidrit-Co-4,4'-oksidianilin)</td><td>Sigma Aldrich</td><td>575801</td><td>PI öncüsü</td></tr><tr><td>Poli (etilen-ko-vinil asetat)</td><td>Sigma Aldrich</td><td>437247-250G</td><td>Sızma için polimer</td></tr><tr><td>Poli (vinil alkol)</td><td>Sigma Aldrich</td><td>341584-25G</td><td></td></tr><tr><td>Polietilen tereftalat (PET)</td><td>Amazon</td><td>KS-6304-21-11</td><td>Tip D Şeffaf PET Levha .0005" Kalın x 27" Genişlik x 10 Ft Uzunluk 1 adet</td></tr><tr><td>Potansiyostat</td><td>Biyolojik</td><td>SP-200 Serisi</td><td>Elektriksel stimülasyon</td></tr><tr><td>Fırına Karşı Direnç</td><td> Sevkiyat</td><td>LCC1-15-5</td><td></td></tr><tr><td>Taramalı elektron mikroskobu</td><td>Carl Zeiss</td><td>Merlin</td><td>Morfoloji karakterizasyonu için araç</td></tr><tr><td>silikon gofret </td><td>NOVA Elektronik Malzemeler</td><td>HS39626</td><td></td></tr><tr><td>Silikon yapıştırıcı</td><td>TEFE</td><td>KWIK-SIL-S</td><td>Kapsülleme</td></tr><tr><td>Sodyum Borat</td><td>Sigma Aldrich</td><td>SX0355 Serisi</td><td></td></tr><tr><td>SOI gofret</td><td>Ultrasil</td><td>3-10541</td><td>Tip-Yönelim:P/B(100) DT:7+/-1um DR:<. 005 Ohmcm HT:300+/-10um HR:1-30 Ohmcm Kutu:1um+/-5% UD-13998/UH-13962</td></tr><tr><td>SU-8 2002</td><td>Mikrokimyasallar</td><td>SU-8 2000 Serisi</td><td></td></tr><tr><td>SU-8 geliştiricisi</td><td>Mikrokimyasallar</td><td>SU-8 2000 Serisi</td><td></td></tr><tr><td>Islak mendil yapıştırıcısı</td><td>3 milyon</td><td>1469SB</td><td></td></tr><tr><td>Whatman kalitatif filtre kağıdı, Sınıf 1</td><td>Sigma Aldrich</td><td>WHA1001150</td><td>Karbon desenleme için alt tabaka</td></tr></tbody></table>

sağlıklı ve İskemik ex vivo sıçan kalplerinde Çift yönlü elektrik ve optoelektronik arayüzler

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Sağlıklı ve İskemik Ex Vivo Sıçan Kalplerinde Çift Yönlü Elektrik ve Optoelektronik Arayüzler

Electrophysiological studies are pivotal in exploring interactions between materials and cardiac biointerfaces. Recent advancements have introduced ...

bidirectional-electrical-optoelectronic-interfaces-healthy-ischemic

Research

JoVE Journal

Bioengineering

Biyomühendislik

Bu makale, potansiyometrik boya kullanarak (di-8-ANEPPS) Langendorff perfüze sıçan kalpleri yüzeyinde optik görüntü aksiyon potansiyeli hareketi yüksek bir zamansal ve mekansal çözünürlükte tekniği açıklar.

Langendorff perfüze sıçan Kalpler Optik Haritalama

Bu makale, panoramik görüntüleme sistemi kullanılarak Langendorff perfüze tavşan kalbinde, optik haritalama deneylerini için temel prosedürleri ve ikili (voltaj ve kalsiyum) görüntüleme yöntemidir.

Çok parametreli Langendorff perfüze Tavşan Kalp Optik Haritalama

Bu çalışmanın amacı, kardiyak dinamiği n çevirisel bir hayvan modeli kullanarak araştırmak için bir yöntem oluşturmaktır. Açıklanan deneysel yaklaşım, izole, bozulmamış bir domuz kalp modelindeki elektriksel aktiviteyi değerlendirmek için elektrofizyolojik bir çalışma ile birlikte çift emisyonlu optokardiografi içerir.

Ex Vivo Langendorff perfüzyonlu Kalplerin Optokardiyografi ve Elektrofizyoloji Çalışmaları

Bu protokol, preklinik ilaç testi için insan kardiyak dilimlerinin kesilmesi ve kültüre edilmesi prosedürünü açıklar ve bu dilimlerden aynı anda transmembran voltajı ve hücre içi kalsiyum sinyallerini kaydetmek için optik haritalamanın kullanımını ayrıntılarıyla açıklar.

İnsan Organotipik Kardiyak Dilimlerinin Çift Voltaj ve Kalsiyum Optik Haritalaması ile Preklinik Kardiyak Elektrofizyoloji Değerlendirmesi

Bu makalede, minimal invaziv bir yaklaşım kullanarak sıçanlarda miyokardiyal iskemi ve sonraki kronik reperfüzyon gerçekleştirmek için etkili bir yöntem sunar. Ayrıca sıçanların sol ventrikül hemodinamik fonksiyonu ekokardiyografi ve izole çalışma kalp yöntemleri ile değerlendirilmektedir.

Sıçanlarda Miyokard İnfarktüsü İndükleyen Yarı-Minimal İnvaziv Yöntem ve İzole Çalışan Kalp Sistemi Ile Kardiyak Fonksiyonun Değerlendirilmesi

Bu çalışma, transgenik channelrhodopsin-2 (ChR2) farelerinin bozulmamış murin kalplerinin kardiyak ritmini, bir mikro-LED dizisi ile lokal fotostimülasyon ve epikardiyal membran potansiyelinin eşzamanlı optik haritalamasını kullanarak kontrol etmek için bir yöntem bildirmektedir.

Murin Kalplerde Optogenetik Çok Bölgeli Fotostimülasyon Uygulayarak İleri Kardiyak Ritim Yönetimi

Bu protokol, yüksek zamansal ve uzamsal çözünürlüğe sahip transmembran voltajının ve hücre içi Ca2+ geçici akımlarının elektrofizyolojik ölçümleri de dahil olmak üzere, katekolaminerjik polimorfik ventriküler taşikardiden etkilenen vahşi tip ve knock-in hayvanlardan elde edilen fare kalplerinin çift boyutlu optik haritalamasını sunar.

Katekolaminerjik Polimorfik Ventriküler Taşikardi RyR2R2474S Knock-In Farelerinden Kalplerin Çift Boyutlu Optik Haritalaması

Bu protokol, transgenik fare kalplerinde intrinsik kardiyak nöronların optogenetik stimülasyonu için bir yöntemi göstermektedir. Açıklanan yaklaşım, ex vivo perfüze kalplerde ani kardiyak nöron aktivasyonunun kinetiğini ve kolinerjik ve katekolaminerjik aktivite arasındaki etkileşimleri araştırmak için kullanılır.

Eksize Edilmiş Perfüze Fare Kalplerinde İntrinsik Kardiyak Otonomik Nöronların Optogenetik Aktivasyonu

Hematopoez için 3D kültür sistemi, insan kordon kanı ve lösemiye kemik iliği hücreleri kullanılarak anlatılmıştır. Metodu hücre dışı matris proteinlerine ile kaplanmış bir emici sentetik poliüretan iskele kullanımına dayanmaktadır. Bu yapı iskelesi hücreleri geniş bir uyum sağlamak için uyarlanabilir.

Normal ve Anormal İnsan Hematopoezin ex vivo Mimicry

Için Mekanik-adaptif Polimer Nanokompozitler bir çevre kontrollü Mikrogerilim Test<em&gt; Ex vivo</em&gt; Karakterizasyonu

Keşfedin çift yönlü elektrik ve optoelektronik arayüzlerle sağlıklı ve iskemik ex vivo sıçan kalplerinde biyoelektronik malzeme testleri. Bu yöntem kalp stimülasyonu, kayıt ve miyokard infarktüsü modellemesi için kullanılır.

Sağlıklı ve İskemik Ex Vivo Sıçan Kalplerinde Çift Yönlü Elektrik ve Optoelektronik Arayüzler

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