Name: Safen Sinir Yoluyla Hedeflenen Kas Reinnervasyonunu Kullanarak Nöroma Ağrısı Tedavi Seçeneklerini İncelemek için Yeni Cerrahi Kemirgen Modeli (Video) | JoVE Journal
Uploaded: 2025-11-14T13:55:00.000+00:00
Duration: 7 min
Description: Keşfedin nöroma ağrısı ve cerrahi tedavileri çalışmak için geliştirilen yeni kemirgen modelini. Mikrocerrahi, sinir stimülasyonu ve histolojik analizlerle translasyonel sinir ağrısı araştırmalarına katkı sağlar.

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</ol>

<table><tbody><tr><td>Karprofen</td><td>Yerel Veteriner Eczanesi</td><td>N/a</td><td>Yerel veteriner eczanesi karprofen seyreltmesini hazırlar</td></tr><tr><td>Pamuk çubukları</td><td>Nobamed</td><td>974255</td><td>&mdash;</td></tr><tr><td>Elektrikli jilet</td><td>Eskülap</td><td>GT421</td><td></td></tr><tr><td>Elektrokoterlik</td><td>Güzel Bilim Araçları</td><td>18010-00</td><td>&mdash;</td></tr><tr><td>Etanol %70</td><td>Interchema BV</td><td>400406</td><td>&mdash;</td></tr><tr><td>Ethilon 10.0</td><td>Johnson & Johnson</td><td>BV130-3: kod 2820G</td><td></td></tr><tr><td>Ethilon 11.0</td><td>Johnson & Johnson</td><td>BV50-3L kodu 2881G</td><td></td></tr><tr><td>Ethilon 4.0</td><td>Johnson & Johnson</td><td>1854G: kod 1854G</td><td>-</td></tr><tr><td>Ethilon 6.0</td><td>Johnson & Johnson</td><td>BV130-5: kod 2809G</td><td></td></tr><tr><td>Ethilon 8.0</td><td>Johnson & Johnson</td><td>BV130-5: kod 2808G</td><td>&mdash;</td></tr><tr><td>Ethilon 9.0</td><td>Johnson & Johnson</td><td>BV130-3: kod 2819G</td><td></td></tr><tr><td>Muayene eldivenleri nitril</td><td>Sempermed GmbH</td><td>1065920</td><td></td></tr><tr><td>Göz koruması</td><td>3M&trade; Sağlık Hizmetleri</td><td>71512-00001M</td><td></td></tr><tr><td>Cam Boncuk Sterilizatörü</td><td>VanPel laboratuvar ekipmanları</td><td>GBS300H</td><td></td></tr><tr><td>GraphPad Prizması</td><td>GraphPad Software, San Diego, Kaliforniya ABD</td><td>&nbsp; Sürüm 10</td><td></td></tr><tr><td>Isıtma pedi</td><td>Davranış Bilimi</td><td>CS-HP-2005</td><td></td></tr><tr><td>İzoflo (izofluran)</td><td>Zoetis / Dechra Veterinerlik Ürünleri</td><td>B506</td><td>&mdash;</td></tr><tr><td>Lidokain %1</td><td>Henry Schein</td><td>809755</td><td></td></tr><tr><td>Ağ taban kafesleri</td><td>Stoelting Şirketi.</td><td>57816, 57824</td><td>&mdash;</td></tr><tr><td>Mikro forseps</td><td>Güzel Bilim Araçları</td><td>11251-35</td><td>&mdash;</td></tr><tr><td>Mikro iğne tutucu</td><td>Güzel Bilim Araçları</td><td>12076-12</td><td>&mdash;</td></tr><tr><td>Mikro makas</td><td>Güzel Bilim Araçları</td><td>15019-10</td><td>&mdash;</td></tr><tr><td>Mikro cımbız</td><td>Güzel Bilim Araçları</td><td>11254-20</td><td>&mdash;</td></tr><tr><td>NaCl %0,9</td><td>Trademed</td><td>H7 1000-FRE</td><td>&mdash;</td></tr><tr><td>İğne 25G ve Times; 1"</td><td>Becton, Dickinson & Şirket</td><td>300400</td><td></td></tr><tr><td>İğne tutacağı</td><td>Güzel Bilim Araçları</td><td>12004-16</td><td>&mdash;</td></tr><tr><td>Sinir uyarıcısı</td><td>&nbsp; (VARI-STIM Sinir lokatoru)</td><td>REF 856200</td><td></td></tr><tr><td>RandoMice yazılımı</td><td>van Eineige ve diğerleri &nbsp; Leiden</td><td>Sürüm 1.1.7</td><td></td></tr><tr><td>Kemirgen rektal probu</td><td>Dünya Hassas Aletleri</td><td>NC9506514</td><td></td></tr><tr><td>Skalpel</td><td>Güzel Bilim Araçları</td><td>10003-12</td><td>&mdash;</td></tr><tr><td>Makas</td><td>Güzel Bilim Araçları</td><td>14001-12</td><td>&mdash;</td></tr><tr><td>Duyusal değerlendirici</td><td>Linton Enstrümantasyonu</td><td>514007&ndash; 514015</td><td>0,6 g ile 15 g monofilamentler</td></tr><tr><td>Stereo cerrahi mikroskop</td><td>Leica</td><td>A60 F</td><td>&mdash;</td></tr><tr><td>Steril gazlı bez pedler</td><td>Nobamed</td><td>740113</td><td></td></tr><tr><td>Steril göz kayganlaştırıcı merhemi</td><td>Alcon&nbsp;</td><td>&lrm; B00BRLSC8S</td><td></td></tr><tr><td>Delikli steril levha</td><td>Evercare / OneMed</td><td>1555-01</td><td>&mdash;</td></tr><tr><td>Cerrahi bıçak numarası. 15</td><td>Güzel Bilim Araçları</td><td>10015-00</td><td>&mdash;</td></tr><tr><td>Cerrahi yüz maskesi</td><td>Medline Endüstrileri, Inc.</td><td>MSK1002</td><td></td></tr><tr><td>Şırınge luer kilidi 2 ml</td><td>Becton, Dickinson & Şirket</td><td>300613</td><td></td></tr><tr><td>Cizbit</td><td>Güzel Bilim Araçları</td><td>11617-12</td><td>&mdash;</td></tr></tbody></table>

safen sinir yoluyla hedeflenen kas reinnervasyonunu kullanarak nöroma ağrısı tedavi seçeneklerini İncelemek için yeni cerrahi kemirgen modeli

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

Safen Sinir Yoluyla Hedeflenen Kas Reinnervasyonunu Kullanarak Nöroma Ağrısı Tedavi Seçeneklerini İncelemek için Yeni Cerrahi Kemirgen Modeli

This protocol describes a novel surgical model to study nerve pain and surgical treatment in rats. Traditional neuroma models use mixed nerves, although ...

novel-surgical-rodent-model-for-studying-neuroma-pain-treatment

Research

JoVE Journal

Neuroscience

Sinirbilim

Ayrılan Sinir Sakatlık hayvan modeli kalan sural sinir zedelemeden, siyatik sinirin kısmi denervasyon aşağıdaki tibial ve peroneal sinir dallarının lezyon periferik nöropatik ağrı bir fare modeli olarak burada açıklanmıştır. Mekanik allodini kaynaklanan davranış değişikliği von Frey filamentler miktarı.

Fare İndüklenmiş Mekanik allodini ayrılan sinir hasarı (SNI) Model

Kaynak: Brakkee, E. M., et al. Sıçanlarda Tibial Nöroma Transpozisyon Modelinde Cerrahi ve Davranışsal Test. J. Vis. Uzm.  (2023). Bu videoda, bir sıçan tibial nöroma transpozisyonu (TNT) modeli oluşturmak için bir prosedür gösterilmektedir. Anestezi uygulanmış bir sıçanın arka bacağındaki tibial siniri açığa çıkardıktan sonra, siniri kesin. Daha sonra, deri altı bir tünel oluşturun, kopan siniri tünelden geçirin ve yerine dikin. Reinnervasyon için bir hedefin yokluğunda, kopmuş sinirden...

Tibial Nöroma Transpozisyonunun Sıçan Modelinin Oluşturulması

Nöropatik ağrı somatosensory sistemini etkileyen bir yara ya da hastalık, bir sonucudur. Farelerde nöropatik ağrı "ağzı model" siyatik sinirin ana dal etrafında bir polietilen manşetin implantasyon oluşur. Mekanik alodinia von Frey filamentleri kullanılarak test edilir.

Farelerde Nöropatik Ağrı Siyatik Sinir cuffing Modeli

Modifiye cerrahi, hem ortak peroneal hem de sural sinirleri yaralamak için sadece bir ligasyon ve bir kesi gerektiren fare veya sıçan korunmuş sinir yaralanması modeli için basitleştirilmiş bir yöntemdir.

Farelerde Nöropatik Ağrının Modifiye Edilmiş Korunmuş Sinir Yaralanması Cerrahisi Modeli

Parsiyel siyatik sinir ligasyonu, termal ve mekanik uyaranlara abartılı tepkilerle karakterize uzun süreli kronik nöropatik ağrıya neden olur. Nöropatik ağrının bu fare modeli, ağrı yönetimi için yenilikçi terapileri incelemek için yaygın olarak kullanılır. Bu makalede, standardizasyonu ve tekrarlanabilirliği artırmak için cerrahi prosedür ayrıntılı olarak anlatılmaktadır.

Kısmi Siyatik Sinir Ligasyonu: Yeni Tedavilerin Antinosiseptif Etkisini İncelemek için Kronik Nöropatik Ağrının Bir Fare Modeli

Bu protokol, tibial sinirin lezyonunu ve ardından proksimal sinir ucunun subkutan pretibial veya lateral pozisyona doğru transpozisyonunu gerektiren tibial nöroma transpozisyon modelini tanımlar. Nöroma ağrısı ve plantar hiperaljezinin davranışsal testleri, Von Frey monofilamentleri kullanılarak ölçülür.

Sıçanlarda Tibial Nöroma Transpozisyon Modelinde Cerrahi ve Davranışsal Test

Burada, uluslararası, randomize kontrollü bir çalışma (RCT) bağlamında amputasyon sonrası nöropatik ağrıyı tedavi etmek için Rejeneratif Periferik Sinir Arayüzü (RPNI) cerrahisini gerçekleştirmek için cerrahi prosedürü açıklıyoruz (ClinicalTrials.gov, NCT05009394). RCT, RPNI'yi diğer iki cerrahi teknikle, yani Hedefli Kas Reinnervasyonu (TMR) ve kas içi transpozisyon ile birlikte nöroma eksizyonu ile karşılaştırır.

Rejeneratif Periferik Sinir Arayüzü: Postamputasyon Ağrısında Randomize Kontrollü Bir Çalışma İçin Cerrahi Protokol

Protokol, Hedefe Yönelik Kas Reinnervasyonu (TMR) kullanılarak amputasyon sonrası ağrının tedavisi için cerrahi prosedürü özetlemektedir. TMR, özellikle Rejeneratif Periferik Sinir Arayüzü (RPNI) ve nöroma eksizyonu olmak üzere diğer iki cerrahi teknikle karşılaştırılacak ve ardından uluslararası, randomize kontrollü bir çalışma bağlamında kas içine hemen gömülecektir.

Hedefe Yönelik Kas Reinnervasyonu: Postamputasyon Ağrısında Randomize Kontrollü Bir Çalışma İçin Cerrahi Protokol

Bu protokol, farelerde diz altı amputasyonun nasıl yapılacağını ve amputasyonla ilişkili ağrıyı tedavi etmek ve önlemek stratejilerini araştırmak ve amputasyonla ilişkili ağrı mekanizmalarını daha iyi anlamak için hemen hedefli kas reinnervasyonu (iTMR) yapılmasını gösterir.

Fare Arka Diz Altı Amputasyon Modeli ve Hemen Hedeflenmiş Kas Reinnervasyonu

Insan beyninde riskli ve belirsiz seçenekleri öznel değer nöral temsiline belirlemek için fonksiyonel MRI ve davranışsal yöntemlerin kullanılması.

Deneysel İktisat ve Fonksiyonel MRI yöntemleri kullanarak Riskli ve belirsiz Seçenekleri Sübjektif Değer Ölçme

Keşfedin nöroma ağrısı ve cerrahi tedavileri çalışmak için geliştirilen yeni kemirgen modelini. Mikrocerrahi, sinir stimülasyonu ve histolojik analizlerle translasyonel sinir ağrısı araştırmalarına katkı sağlar.

Safen Sinir Yoluyla Hedeflenen Kas Reinnervasyonunu Kullanarak Nöroma Ağrısı Tedavi Seçeneklerini İncelemek için Yeni Cerrahi Kemirgen Modeli (Video) | JoVE Journal

Safen Sinir Yoluyla Hedeflenen Kas Reinnervasyonunu Kullanarak Nöroma Ağrısı Tedavi Seçeneklerini İncelemek için Yeni Cerrahi Kemirgen Modeli

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