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JoVE Journal
Neuroscience

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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model
 

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

Article DOI: 10.3791/2252
October 9th, 2010

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Summary October 9th, 2010

The intensely studied nematode worm Caenorhabditis elegans can be transgenically engineered to express the human β-amyloid peptide (Aβ). Induced expression of Aβ in C. elegans muscle leads to a rapid, reproducible paralysis phenotype that can be used to monitor treatments that modulate Aβ toxicity.

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