Convection-Enhanced Delivery of Polyethylene Glycol-Coated Charged Liposomes into a Rat Brain Tumor

Take a Hamilton syringe containing a suspension of polyethylene glycol or PEG-coated liposomes with a charged surface encapsulating a drug targeted against a brain tumor.

The drug encapsulation enhances tumor cell specificity and reduces neurotoxicity.

Attach the syringe to a fine needle and connect it to a micro-infusion pump. This setup is known as convection-enhanced delivery or CED.

Take a rat with an implanted brain tumor.

Using the CED system, administer the liposomal solution directly into the tumor at a controlled rate over a specified duration.

The PEG coating on the liposomes aids in their distribution throughout the tumor, while the charged surface facilitates interaction with the cell membrane, promoting their internalization.

Evaluate the distribution and therapeutic efficacy of the drug on the tumor.