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JoVE Journal
Bioengineering

This content is Open Access.

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
 

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Article doi: 10.3791/2460
December 9th, 2010 Usage Statistics

Summary December 9th, 2010

Nanoparticles of indinavir, ritonavir, efavirenz and atazanavir were manufactured using wet milling, homogenization and ultrasonication. These nanoformulations, collectively termed nanoformulated antiretroviral therapy (nanoART), assessed macrophage-based drug delivery. Monocyte-derived macrophage nanoART uptake, retention and sustained release were determined. These preliminary studies suggest the potential of nanoART for clinical use.

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