Using ²³Na Magnetic Resonance Imaging to Measure Sodium in Muscle Tissues

Place the patient's lower leg within the radiofrequency coil of the magnetic resonance imaging or MRI machine.

The coil contains various sodium concentrations as standards to measure tissue sodium accumulation.

Initiate a sodium-MRI scan.

The coil detects fluctuations in the MR signal intensity emitted from the tissue, influenced by the distribution and concentration of sodium ions.

Obtain a total tissue sodium map displaying areas with varying color intensities corresponding to the sodium levels.

Compare these intensities with standard sodium concentrations, which aid in measuring total tissue sodium levels.

Bright colors indicate higher levels, while darker colors indicate lower levels.

Next, capture signals corresponding to the fat and water content of the tissue to generate images of the non-muscle regions.

Subtract non-muscle regions from the total tissue sodium map to generate a refined image and measure muscle tissue sodium content.

Begin by embedding calibration standard sodium chloride solutions in the MRI phantom holder of the coil.

Position the participant on the MRI table in a supine position.

For imaging of the calf at the mid-gastrocnemius muscle, place the phantom ho