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Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease
 

Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease

Article DOI: 10.3791/3234
February 14th, 2012

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Summary February 14th, 2012

A protocol for performing unilateral 6-OHDA lesions of the medial forebrain bundle in mice is described. This method has a low mortality rate (13.3 %) with 89% of the surviving animals showing >95% loss of striatal dopamine and 90.63±-4.02 % ipsiversive rotational bias towards the side of the lesion.

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