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Journal / Bioengineering / Directed Cellular Self-Assembly to Fabricate…
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Bioengineering

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JoVE Journal Bioengineering
Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
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Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Article DOI: 10.3791/3366 • 08:01 min • November 25th, 2011
November 25th, 2011 •
1, 1, 1, 1
1Biomedical Engineering Department, Worcester Polytechnic Institute

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This article outlines a versatile method to create cell-derived tissue rings by cellular self-assembly. Smooth muscle cells seeded into ring-shaped agarose wells aggregate and contract to form robust three-dimensional (3D) tissues within 7 days. Millimeter-scale tissue rings are conducive to mechanical testing and serve as building blocks for tissue assembly.

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Directed Cellular Self-assembly Fabricate Cell-derived Tissue Rings Biomechanical Analysis Tissue Engineering Coronary Artery Bypass Surgery Autologous Donor Vessels Vascular Tissue Engineering Living Vascular Models Cell-based Methods Smooth Muscle Cells Agarose Wells Cohesive Tissue Ring Mechanical Analysis Physiological Analysis Biochemical Analysis Histological Analysis Ultimate Tensile Strength
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