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JoVE Journal
Bioengineering

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A Cre-Lox P Recombination Approach for the Detection of Cell Fusion In Vivo
 

A Cre-Lox P Recombination Approach for the Detection of Cell Fusion In Vivo

Article doi: 10.3791/3581
January 4th, 2012

Summary January 4th, 2012

A method to track cell fusion in living organisms over time is described. The approach utilizes Cre-LoxP recombination to induce luciferase expression upon cell fusion. The luminescent signal generated can be detected in living organisms using biophotonic imaging systems with a sensitivity of detection of ˜1,000 cells in peripheral tissues.

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