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Immunology and Infection

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JoVE Journal Immunology and Infection
Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Article DOI: 10.3791/3778 • 08:38 min • April 9th, 2012
April 9th, 2012 •
1, 2, 2
1Department of Medicine, Section of Cardiology, St. John-Providence Health System, 2Department of Immunology and Microbiology, Wayne State University School of Medicine

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Summary
Automatic Translation

Certain mouse strains are able to resist induction of experimental autoimmune encephalomyelitis (EAE) with myelin basic protein. Described here is a simple immunization protocol that reverses the unresponsiveness and induces paralytic disease in several typical EAE resistant mouse stains.

Tags

Experimental Autoimmune Encephalomyelitis EAE Mouse Strains Adoptive Transfer Antigenic Challenge Central Nervous System Mononuclear Cells Paralytic Disease Multiple Sclerosis Genetic Control C57BL/6 Mice Myelin Basic Protein Antigen Processing Antigen Presentation Encephalitogenic T Cell Clones Cellular Adoptive Transfer System
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