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Medicine

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
 

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Article doi: 10.3791/3947
July 10th, 2012 Usage Statistics

Summary July 10th, 2012

Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation.

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