Orthotopic Lung Transplant
Orthotopic Lung Transplant - Related Videos
08:22
Orthotopic Left Lung Transplantation in Rats
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Cited by 1 •
2025
This protocol describes an improved technique for orthotopic left lung transplantation in rats, focusing on reducing operational difficulty and improving survival rates.
10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Cited by 20 •
2012
Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation.
18:25
Orthotopic Liver Transplantation in Rats
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Cited by 31 •
2012
We present an easy-to-establish revision of the classical two-cuff technique for orthotopic liver transplantation in rat.
07:15
Orthotopic Hind Limb Transplantation in the Mouse
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Cited by 24 •
2016
This novel model for orthotopic hind limb transplantation in the mouse, applying a non-suture cuff technique for super-microvascular anastomosis, provides a powerful tool for in vivo mechanistic immunological research related to vascularized composite allotransplantation (VCA).
09:16
Orthotopic Small Bowel Transplantation in Rats
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Cited by 4 •
2012
Small bowel transplantation has become an accepted treatment option for patients with irreversible intestinal failure. Our experimental model of orthotopic small bowel transplantation in rats serves as a reliable tool to address underlying immunologic and inflammatory processes that complicate intestinal transplantation.
FAQs
Successful integration requires surgeons to establish continuous pathways between the donor bronchi and the recipient’s airways, as well as between the donor pulmonary blood vessels and the recipient’s circulation. Positioning the graft in the recipient’s normal anatomical location supports this reconstruction and allows the transplanted lungs to participate in respiratory function after surgery.
Immunosuppressive therapy limits the recipient’s immune response against the transplanted lungs. Without this management, immune rejection can threaten graft function and the benefits of transplantation. Because the graft remains exposed to this risk, immunosuppressive treatment forms a continuing part of care rather than a short-term measure limited to the operation itself.
Careful donor matching helps clinicians select donor lungs for an appropriate recipient before transplantation. This decision is part of the preparation for graft placement and is especially important because the transplanted organs must connect with the recipient’s airways and circulation. Matching therefore supports the technical and medical planning required for a successful transplant.
The principal long-term concerns identified for this procedure are infection and immune rejection of the graft. Immunosuppressive therapy helps limit rejection, while postoperative monitoring helps clinicians watch the recipient’s condition over time. Lifelong management is necessary because both risks remain relevant after the immediate surgical recovery and can affect continued graft function.
Orthotopic Lung Transplant may be considered for selected patients with end-stage lung disease, including cystic fibrosis, chronic obstructive pulmonary disease, pulmonary fibrosis, or pulmonary hypertension. The procedure is not presented as a general treatment for every respiratory disorder; candidacy depends on severe disease and the careful assessment required for transplantation.
The pathway includes selecting an appropriate patient, arranging careful donor matching, surgically connecting the donor bronchi and pulmonary blood vessels, and using immunosuppressive therapy after graft placement. Postoperative monitoring then focuses on the transplanted lungs and the risks of infection and rejection. Ongoing follow-up supports long-term management after respiratory function is restored.