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Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Article DOI: 10.3791/3986-v • 12:47 min • May 14th, 2012
May 14th, 2012 •
1, 1, 1, 1
1Department of Microbiology and Immunology, Pennsylvania State University College of Medicine

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Generation of T lymphocytes from induced pluripotent stem (iPS) cells gives an alternative approach of using embryonic stem cells for T cell-based immunotherapy. The method shows that by utilizing either in vitro or in vivo induction system, iPS cells are able to differentiate into both conventional and antigen-specific T lymphocytes.

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Directed Differentiation Induced Pluripotent Stem Cells T Lymphocytes Adoptive Cell Transfer Antigen-specific CD8+ Cytotoxic T Lymphocytes T Cell Receptors Cytotoxins Cytokines Highly Reactive CTLs Immunotherapy Homeostatic Cytokines ACT-based Therapies TCR Transduction Self-renewable Stem Cells Immune Reconstitution Embryonic Stem Cells Hematopoietic Stem Cells In Vitro Cell Culture IPS Cell Technology Gene Delivery
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