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JoVE Journal
Immunology and Infection

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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
 

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Article doi: 10.3791/4029
July 16th, 2012

Summary July 16th, 2012

We describe two methods for conditional trans-complementation of hepatitis C virus (HCV) assembly and the completion of the full viral life cycle, which rely on heterokaryon formation. These techniques are suitable to screen for cell lines that express dominant restriction factors, which preclude production of infectious HCV progeny.

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