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Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme
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Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme

Article DOI: 10.3791/4089 • 10:53 min • September 25th, 2012
September 25th, 2012 •
1, 1, 1, 1, 1
1Department of Radiation Oncology, University of Pennsylvania

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We describe an integrated method for the precise, stereotactic implantation of human glioblastoma multiforme cells into the brains of nude mice and subsequent serial in vivo imaging to monitor growth and response to treatment of the resultant xenografts.

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Stereotactic Intracranial Implantation In Vivo Bioluminescent Imaging Tumor Xenografts Mouse Model System Glioblastoma Multiforme High-grade Primary Brain Cancer Median Survival Standard Tri-modality Treatment Surgical Resection Radiation Therapy Temozolomide Chemotherapy Therapeutic Approaches Animal Models Tumor Growth Treatment Response Bio-imageable GBM Cancer Cells Nude Mice Anatomic Locations In Vivo Bioluminescent Imaging Intracranial Xenograft Growth Perioperative Morbidity Mortality
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