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Biology

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Examining BCL-2 Family Function with Large Unilamellar Vesicles
 

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Article DOI: 10.3791/4291
October 5th, 2012

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Summary October 5th, 2012

Biochemically-defined large unilamellar vesicles (LUVs) are a convenient model system to analyze BCL-2 family interactions with immediate implications in better understanding the mitochondrial pathway of apoptosis. A method to produce LUVs, along with standard BCL-2 family protein combinations and controls to examine LUV permeabilization, are presented.

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