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双侧颈总动脉闭塞足够的预处理刺激诱导局灶性脑缺血早期缺血耐受

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JoVE Journal Medicine

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

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双侧颈总动脉闭塞足够的预处理刺激诱导局灶性脑缺血早期缺血耐受

DOI:

•

07:46 min

•

May 09, 2013

•

Lukas Julius Speetzen, Matthias Endres, Alexander Kunz

¹Department of Neurology, Center for Stroke Research Berlin,Charité – Universitätsmedizin Berlin, Germany

Chapters

00:05Title
01:19Positioning of the LDF Probe and LDF Monitoring
02:24Bilateral Common Carotid Artery Occlusion
04:10Middle Cerebral Artery Occlusion
06:19Results: Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
07:16Conclusion

Summary

Automatic Translation

有越来越多的证据，即缺血预处理（PC） - 非伤害性脑缺血大脑的挑战 - 赋予随后破坏性的缺血性损伤的瞬态保护。我们建立双侧颈总动脉闭塞（夹闭双侧颈总动脉）作为预处理刺激诱导早期缺血耐受（IT）C57BL6 / J小鼠局灶性脑缺血（大脑中动脉闭塞，缺血引起的）。

Tags

Bilateral Common Carotid Artery Occlusion Preconditioning Stimulus Early Ischemic Tolerance Focal Cerebral Ischemia Ischemic Preconditioning Non-damaging Ischemic Challenge Transient Protection Damaging Ischemic Insult C57Bl6/J Mice Methodology

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