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Neuroscience

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JoVE Journal Neuroscience
Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue
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Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Article DOI: 10.3791/50126-v • 11:31 min • February 11th, 2013
February 11th, 2013 •
1, 1, 2, 1, 1,2
1Weldon School of Biomedical Engineering, Purdue University, 2Department of Biological Sciences, Purdue University

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Summary
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Here we present a histological method for capturing, labeling, optically clearing, and imaging the intact brain tissue interface around chronically implanted microdevices in rodent brain tissue. Results from the techniques comprising this method are useful for understanding the impact of various penetrating brain-implants on their surrounding tissue.

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Brain-implanted Microdevices Microelectrode Arrays Histological Characterization Surrounding Tissue Glial Scar Explanting Devices Cortical-implanted Devices Rodent Brain Tissue Fixative Fluorescent Antibody Labeling Optical Clearing Methods Tissue Section Biological Interface
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