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2-Vessel Occlusion/Hypotension
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2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

Article DOI: 10.3791/50173 • 09:29 min • June 22nd, 2013
June 22nd, 2013 •
1,2,3, 2,3
1Department of Emergency Medicine, Wayne State University School of Medicine, 2Cardiovascular Research Institute, Wayne State University School of Medicine, 3Department of Physiology, Wayne State University School of Medicine

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Summary
Automatic Translation

Bilateral carotid occlusion coupled with systemic hypotension produces global brain ischemia in the rat, resulting in damage to the hippocampus with reproducible severity. Animal subjects are impaired with predictable patterns of brain damage, they recover expediently, and mortality rates are comparatively low.

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2-Vessel Occlusion/Hypotension Rat Model Global Brain Ischemia Cardiac Arrest Resuscitation Brain Damage Ischemia Reperfusion Hippocampal Neurons CA1 Region Therapeutic Interventions Mechanisms Of Cerebral Damage Bilateral Carotid Vessel Occlusion Hypotension Reproducible Model Selective Brain Regions Systemic Blood Pressure Control Temperature Control Anesthesia Regimen Post-operative Care Ischemic Insult Cell Death
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