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2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia
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2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

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19,785 Views

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09:29 min

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June 22, 2013

DOI:

10.3791/50173-v

DOI:
10.3791/50173-v

•

09:29 min
June 22, 2013

•

2 Views
,
1Department of Emergency Medicine,Wayne State University School of Medicine, 2Cardiovascular Research Institute,Wayne State University School of Medicine, 3Department of Physiology,Wayne State University School of Medicine

Summary

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Bilateral carotid occlusion coupled with systemic hypotension produces global brain ischemia in the rat, resulting in damage to the hippocampus with reproducible severity. Animal subjects are impaired with predictable patterns of brain damage, they recover expediently, and mortality rates are comparatively low.

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Cite this Article

Sanderson, T. H., Wider, J. M. 2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia. J. Vis. Exp. (76), e50173, doi:10.3791/50173 (2013).

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