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JoVE Journal
Neuroscience

This content is Open Access.

JoVE Journal Neuroscience
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A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

Article DOI: 10.3791/50291
September 2nd, 2013 •
*1,2, *1,2, 1,2
1Institute for Behavioral Genetics, University of Colorado Boulder, 2Department of Psychology and Neuroscience, University of Colorado Boulder
* These authors contributed equally

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Summary
Automatic Translation
September 2nd, 2013

The recent development of neuroscience tools that combine genetics and optics, termed "optogenetics", enables control over neural circuit activity with an unprecedented level of spatial and temporal resolution. Here we provide a protocol for integrating in vivo recording with optogenetic manipulation of genetically-defined subsets of prefrontal cortical and subicular pyramidal neurons.

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