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Assessment of Sensorimotor Function in Mouse Models of Parkinson’s Disease
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Behavior
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JoVE Journal Behavior
Assessment of Sensorimotor Function in Mouse Models of Parkinson’s Disease

Assessment of Sensorimotor Function in Mouse Models of Parkinson’s Disease

DOI:
10.3791/50303-v

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10:32 min

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June 17, 2013

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, ,
1Department of Psychology,University of Cincinnati, 2Department of Neurology,University of Cincinnati

Chapters

  • 00:05Title
  • 01:23Challenging Beam Traversal Procedure
  • 05:22Spontaneous Activity in the Cylinder Procedure
  • 07:26Adhesive Removal Test
  • 09:00Results: Assessment of Sensorimotor Function in Mice
  • 10:04Conclusion

Summary

Automatic Translation

Automatic Translation

In Parkinson's disease and movement disorders in general, sensitive and reliable behavioral assays are essential for testing novel potential therapeutics. Here, we describe a manageable battery of sensorimotor tests for mice that are sensitive to varying degrees of injury to the nigrostriatal system and useful for preclinical studies.

Tags

Keywords: Sensorimotor FunctionMouse ModelsParkinson’s DiseaseBehavioral Outcome MeasuresPreclinical TrialsNigrostriatal DysfunctionSensorimotor TestsGenetic Mouse ModelsDisease-modifying Therapies

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