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Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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Bioengineering
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JoVE Journal Bioengineering
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

DOI:
10.3791/50401-v

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08:08 min

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June 18, 2013

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, , , ,
1Department of Obstetrics, Perinatal Pharmacology,University Hospital Zurich, 2Laboratory for Materials – Biology Interactions,EMPA Swiss Federal Laboratories for Materials Testing and Research, 3Graduate School for Cellular and Biomedical Sciences,University of Bern

Chapters

  • 00:05Title
  • 01:36Preparing the Perfusion System
  • 02:38Cannulating the Placenta
  • 05:01Executing the Pre- and Experimental Phase of Perfusion
  • 06:21Results: Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta Using the Ex vivo Human Placental Perfusion Model
  • 07:44Conclusion

Summary

Automatic Translation

Automatic Translation

The ex vivo dual recirculating human placental perfusion model can be used to investigate the transfer of xenobiotics and nanoparticles across the human placenta. In this video protocol we describe the equipment and techniques required for a successful execution of a placenta perfusion.

Tags

Keywords: Placental PerfusionXenobioticsNanomaterialsPlacental BarrierEx Vivo ModelFetal ExposureNanoparticlesPolystyrene ParticlesTransport RateHuman Placenta

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