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表皮黑色素和防止晒斑的人性化小鼠模型的诱导药物
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Medicine
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Please note that all translations are automatically generated.
Click here for the English version.
表皮黑色素和防止晒斑的人性化小鼠模型的诱导药物
DOI:
10.3791/50670-v
•
12:37 min
•
September 07, 2013
•
Alexandra Amaro-Ortiz
2
,
Jillian C. Vanover
3
,
Timothy L. Scott
2
,
John A. D’Orazio
2,3,4
1
The Markey Cancer Center
,
University of Kentucky College of Medicine
,
2
Graduate Center for Toxicology
,
University of Kentucky College of Medicine
,
3
Department of Molecular and Biomedical Pharmacology
,
University of Kentucky College of Medicine
,
4
Department of Pediatrics
,
University of Kentucky College of Medicine
Chapters
00:05
Title
02:12
Preparation of C57Bl/6 K14-Scf Mice and Topical Forskolin Treatment
04:31
Reflective Colorimetry and Calculating the Minimal Erythematous Dose
08:15
Representative Melanin Induction Results
11:43
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
表皮黑色素是由毛喉素局部应用在皮肤白皙的紫外线敏感的人小鼠模型诱导。 cAMP水平的皮肤和表皮发黑免受紫外线介导的炎症(晒斑)强烈保护如由最小红斑量(MED)法测定的药理操纵。
Tags
Melanocortin 1 Receptor
Mc1r
Stem Cell Factor
Scf
Epidermal Melanin
UV Protection
Forskolin
Minimal Erythematous Dose
MED
Humanized Mouse Model
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