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Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
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1Division of Biology,California Institute of Technology, 2Solomon H. Snyder Department of Neuroscience, Neurology, and Ophthalamology,Johns Hopkins University School of Medicine, 3Department of Radiation Oncology & Molecular Radiation Sciences,Johns Hopkins University School of Medicine, 4Department of Radiation Oncology,University Of Washington Medical Center, 5Institute for Cell Engineering and High-Throughput Biology Center,Johns Hopkins University School of Medicine
Chapters
- 00:05Title
- 01:59Calibration of the CT-guided Laser Platform: Part 1
- 04:15Calibration of the CT-guided Laser Platform: Part 2
- 06:36Preparation of Mouse Subjects for Focal Irradiation
- 08:37Calibration and Experimental Findings
- 11:12Conclusion
The function of adult-born mammalian neurons remains an active area of investigation. Ionizing radiation inhibits the birth of new neurons. Using computer tomography-guided focal irradiation (CFIR), three-dimensional anatomical targeting of specific neural progenitor populations can now be used to assess the functional role of adult neurogenesis.
