A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:05Title
- 01:39Phospho-protein Western Blot
- 03:02Methylcellulose Assay
- 04:24Evaluation of Phospho-protein Inhibition in vivo
- 05:39Evaluation of Anti-leukemia Activity of TKIs in ALL Xenograft Models
- 08:13Results: Biochemical and Functional Effects Mediated by TKIs
- 10:07Conclusion
Receptor tyrosine kinases are ectopically expressed in many cancers and have been identified as therapeutic targets in acute leukemia. This manuscript describes an efficient strategy for pre-clinical evaluation of tyrosine kinase inhibitors for the treatment of acute leukemia.
