Time-lapse microscopy and image processing techniques were used to observe and analyze fibroblast-mediated gel compaction and fibrin fiber realignment in an environmentally controlled bioreactor over a 48 hr period.
De Jesús, A. M., Sander, E. A. Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction. J. Vis. Exp. (83), e50918, doi:10.3791/50918 (2014).