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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
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Behavior
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JoVE Journal Behavior
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

DOI:
10.3791/50978-v

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06:50 min

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December 24, 2013

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, , , ,
1Research and Development Service, John D. Dingell VA Medical Center and Department of Psychiatry & Behavioral Neurosciences,Wayne State University School of Medicine

Chapters

  • 00:05Title
  • 01:22Animal Handling
  • 01:48Marble Burying Test
  • 03:26Nestlet Shredding Test
  • 04:47Results: Compulsive-like Behaviors in Mice
  • 06:10Conclusion

Summary

Automatic Translation

Automatic Translation

Disease, head injury, genetic modifications, and treatment of mice with drugs can have profound effects on behavior. Utilizing well-characterized and validated approaches such as marble burying and nestlet shredding, compulsive-like behaviors can be documented accurately in mice as models of human obsessive-compulsive disorder and autism spectrum disorder.

Tags

Keywords: Marble BuryingNestlet ShreddingRepetitive BehaviorsCompulsive-like BehaviorsObsessive-compulsive Disorder (OCD)Autism Spectrum Disorders (ASD)Animal ModelsMice

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