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JoVE Journal
Engineering

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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
 

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Article doi: 10.3791/51081
October 31st, 2013 Usage Statistics

Summary October 31st, 2013

A methodology for preparing solid-state nanopores in solution for biomolecular translocation experiments is presented. By applying short pulses of high electric fields, the nanopore diameter can be controllably enlarged with subnanometer precision and its electrical noise characteristics significantly improved. This procedure is performed in situ using standard laboratory equipment under experimental conditions.

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