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JoVE Journal
Immunology and Infection

This content is Open Access.

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
 

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

Article DOI: 10.3791/51134
April 1st, 2014

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Summary April 1st, 2014

Neisseria meningitidis is a human specific pathogen that infects blood vessels. In this protocol human microvessels are introduced into a mouse by grafting human skin onto immunocompromised mice. Bacteria adhere extensively to the human vessels, leading to vascular damage and development of the purpuric rash typically observed in human cases.

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