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Indledning af metastatisk brystkræft karcinom ved Målretning af Duktalt epitel med Adenovirus-Cre
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Indledning af metastatisk brystkræft karcinom ved Målretning af Duktalt epitel med Adenovirus-Cre: A Novel transgene mus Model for brystkræft

Article DOI: 10.3791/51171 • 07:14 min • March 26th, 2014
March 26th, 2014 •
*1, *1, 1, 1, 1, 1, 1, 2, 3, 4,5,6, 1
1Tumor Microenvironment and Metastasis Program, Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics, Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center, University of Pennsylvania, 6Center for Advanced Medicine, University of Pennsylvania
* These authors contributed equally

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Aktivering af latente mutationer med adenovirus-Cre i brystkirtler duktalt system resulterer i en klinisk relevant metastatisk brystkræft. Indarbejdelse af en YFP promotor muliggør sporing af distale metastatiske tumorceller. Denne model er nyttig til at studere latent metastase, anti-tumor immunitet og for at udforme nye immunoterapier til behandling af brystkræft.

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Medicine Transgene mus brystcancer metastase intraductal injektion latente mutationer adenovirus-Cre
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