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Lineage-omprogrammering af pericyt-afledte Celler af Voksen Menneskelige hjerne til Inducerede Neuroner
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
DOI:

09:36 min

May 12, 2014

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Chapters

  • 00:05Title
  • 01:34Isolation and Culturing of Adult Human Brain Cells
  • 02:55In vitro Expansion and Characterization of Adult Human Brain Cells
  • 05:15Retroviral Transduction of Pericyte-derived Cells and Reprogramming into Induced Neurons
  • 06:41Results: Reprogramming Adult Brain Cells into Induced Neurons
  • 09:11Conclusion

Summary

Automatic Translation

Målretning hjerne-resident celler til direkte afstamning-omprogrammering giver nye perspektiver for hjernen reparation. Her beskriver vi en protokol om, hvordan man forbereder kulturer beriget med hjerne-resident pericytes fra voksent menneske hjernebarken og konvertere disse til inducerede neuroner ved retrovirusmedieret udtryk for transskriptionsfaktorerne Sox2 og Ascl1.

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