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JoVE Journal
Immunology and Infection

This content is Open Access.

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
 

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Article doi: 10.3791/51601
September 9th, 2014

Summary September 9th, 2014

To counteract pathogen dissemination, host cells reorganize their cytoskeleton to compartmentalize bacteria and induce autophagy. Using Shigella infection of tissue culture cells, host and pathogen determinants underlying this process are identified and characterized. Using zebrafish models of Shigella infection, the role of discovered molecules and mechanisms are investigated in vivo.

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