Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

William S. Phipps; Zhizhong Yin; Candice Bae; Julia Z. Sharpe; Andrew M. Bishara; Emily S. Nelson; Aaron S. Weaver; Daniel Brown; Terri L. McKay; DeVon Griffin; Eugene Y. Chan

doi:10.3791/51743

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Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

JoVE Journal
Biology

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JoVE Journal Biology

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

13,656 Views

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13:59 min

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November 13, 2014

DOI:

10.3791/51743-v

DOI:

10.3791/51743-v

•

13:59 min

November 13, 2014

•

3 Views

William S. Phipps*¹, Zhizhong Yin*¹, Candice Bae¹, Julia Z. Sharpe¹, Andrew M. Bishara², Emily S. Nelson³, Aaron S. Weaver³, Daniel Brown⁴, Terri L. McKay³, DeVon Griffin³, Eugene Y. Chan¹

¹DNA Medicine Institute, ²Harvard Medical School, ³NASA Glenn Research Center, ⁴ZIN Technologies

Summary

Spaceflight blood diagnostics need innovation. Few demonstrations have been published illustrating in-flight, reduced-gravity health diagnostic technology. Here we present a method for construction and operation of a parabolic flight test rig for a prototype point-of-care flow-cytometry design, with components and preparation strategies adaptable to other setups.