Fluidics System
Fluidics System - Related Videos
13:36
Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits
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Cited by 10 •
2010
Controlling and analyzing neural circuits in vivo would be facilitated by a technology for delivery of viruses and other reagents to desired 3-dimensional sets of brain regions. We demonstrate customized fluidic injector array fabrication, and delivery of virally-encoded optical sensitizers, enabling optical manipulation of complex brain circuits.
06:26
Maintaining and Assessing Various Tissue and Cell Types of the Eye Using a Novel Pumpless Fluidics System
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Cited by 2 •
2023
Real-time analysis of live tissue yields important functional and mechanistic data. This paper describes the protocols and critical variables to ensure accurate and reproducible generation of data by a novel and pump-free multi-channel fluidics system that maintains and assesses a wide range of tissue and cell models.
12:32
Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales
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Cited by 2 •
2020
Breakthrough curves (BTCs) are efficient tools to study the transport of bacteria in porous media. Here we introduce tools based on fluidic devices in combination with microscopy and flow cytometric counting to obtain BTCs.
06:12
Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
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2025
Here we present a protocol for constructing an organ-on-chip (OOC) system designed to mimic pneumonectomy. This system investigates the potential correlation between glycocalyx impairment and complications following pneumonectomy.
11:19
Preparation and Testing of Impedance-based Fluidic Biochips with RTgill-W1 Cells for Rapid Evaluation of Drinking Water Samples for Toxicity
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Cited by 12 •
2016
This manuscript describes how to prepare fluidic biochips with Rainbow trout gill epithelial cells for use in a field portable electric cell-substrate impedance sensor. The protocol for running a rapid drinking water toxicity test with the sensor is also described.
FAQs
Liquid or gas movement is driven by a pressure difference, mechanical pumping, or capillary force. Channels provide the routes through which the material travels, while the selected driving mechanism determines how it is introduced and directed. This control lets a biological experiment handle small volumes reproducibly rather than relying on uncontrolled movement.
Pumps and valves provide active control, but they do different jobs. A pump supplies the force that moves fluid, whereas a valve regulates where that fluid can go. Reservoirs hold the liquid or gas before delivery, and channels connect these elements. Together, these components create a controllable path for sample handling and reagent delivery.
Fluidics systems can combine, separate, or deliver materials by controlling their paths through connected channels. Directing streams toward one another supports mixing, while routing them into different paths supports separation or selective delivery. The ability to perform these operations is useful when an assay requires several controlled handling steps within a small-volume biological workflow.
A basic workflow starts by placing samples or reagents in reservoirs and connecting them through channels. Researchers then establish movement with pressure, a pump, or capillary action, using valves to regulate the route. The resulting flow can direct, mix, separate, or deliver material as required, allowing the system to support different biological experimental designs.
Fluidics systems are especially useful for microfluidic assays, where precise handling of small volumes is central to the experiment. They also support cell culture, cell sorting, and diagnostic testing. In these settings, controlled routing and delivery can organize samples and reagents while reducing reagent use, making the approach valuable for compact, repeatable fluid handling.
In organ-on-chip models, fluid control helps reproduce complex biological environments rather than merely holding cells in a static setting. By regulating how liquids move through the model, researchers can study cellular behavior and disease processes under controlled conditions. The same principle makes fluidics relevant when biological experiments require conditions that can be manipulated and reproduced.