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Neuroscience

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JoVE Journal Neuroscience
Real-time Imaging af axonal Transport af Quantum Dot-mærket BDNF i Primary neuroner
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Real-time Imaging af axonal Transport af Quantum Dot-mærket BDNF i Primary neuroner

Article DOI: 10.3791/51899
September 15th, 2014 •
1, 2, 1, 3,4, 1, 1
1Department of Neurosciences, University of California, San Diego, 2School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 3Department of Anesthesiology, University of California, San Diego, 4VA San Diego Healthcare System

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September 15th, 2014

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Axonal transport af BDNF, en neurotrofisk faktor, er afgørende for overlevelse og funktion af flere neuronale populationer. Visse degenerative sygdomme er kendetegnet ved forstyrrelser af axonal struktur og funktion. Vi demonstrerede de anvendte teknikker til at undersøge levende handel med QD-BDNF i mikrofluide kamre anvender primære neuroner.

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