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Biology

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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
 

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Article DOI: 10.3791/51984
December 7th, 2014

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Summary December 7th, 2014

Emergence of genetic resistance against kinase inhibitor therapy poses significant challenge for effective cancer therapy. Identification and characterization of resistant mutations against a newly developed drug helps in better clinical management and next generation drug design. Here, we describe our protocol for in vitro screening and validation of resistant mutations.

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