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Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Article DOI: 10.3791/52012
December 21st, 2014 •
1, 1
1Vascular Biology Program, Department of Surgery, Boston Children's Hospital and Harvard Medical School

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December 21st, 2014

Recapitulation of the organ-specific microenvironment, which stimulates local angiogenesis, is indispensable for successful regeneration of damaged tissues. This report demonstrates a novel method to implant fibrin gels on the lung surface of living mouse in order to explore how the lung-specific microenvironment modulates angiogenesis and alveolar regeneration in adult mouse.

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