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JoVE Journal
Immunology and Infection

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An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
 

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Article doi: 10.3791/52205
February 5th, 2015

Summary February 5th, 2015

To address mechanisms of demyelination and neuronal apoptosis in cortical lesions of inflammatory demyelinating disorders, different animal models are used. We here describe an ex vivo approach by using oligodendrocyte-specific CD8+ T-cells on brain slices, resulting in oligodendroglial and neuronal death. Potential applications and limitations of the model are discussed.

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