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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
JoVE Journal
Behavior
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JoVE Journal Behavior
Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
DOI:

09:29 min

January 09, 2015

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Chapters

  • 00:05Title
  • 01:50Handling and Food Restriction
  • 02:33Magazine Training
  • 03:56Lever Press Training: Pre-training Stage
  • 05:19Lever Press Training: Lever Press Training on a Discrete Trial Schedule
  • 06:23Signal Attentuation and Regular Extinction
  • 07:03Testing
  • 07:45Results: Alterations in Signal Attentuation after Drug Intervention
  • 08:32Conclusion

Summary

Automatic Translation

The goal of the protocol described in this paper is to induce compulsive-like behavior in rats for the study of obsessive-compulsive disorder (OCD). This behavior is precipitated by attenuating a signal indicating that a lever-press response was effective in producing food.

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